Human-pig hybrid embryos given go ahead

A licence to create human-pig embryos to study heart disease has been issued by the fertility watchdog.This marks the third animal-human hybrid embryo licence to be issued by Human Fertilisation and Embryology Authority and the first since the Commons voted in favour of this controversial research last month. An HFEA spokesman said it had approved an application from the Clinical Sciences Research Institute, University of Warwick, for the creation of hybrid embryos. The centre has been offered a 12 month licence with effect from July 1. The effort at the University of Warwick is led by Professor Justin St John. "This new license allows us to attempt to make human pig clones to produce embryonic stem cells," he said, where embryonic stem cells are able to turn into the 200 plus types in the body. "We will take skin cells from patients who have a mutation for certain kinds of heart disease (cardiomyopathy, which makes the heart lose its pumping strength) and put them into pig eggs after their chromosomes have been removed. We will then make embryos so that we can attempt to derive embryonic stem cells which will allow us to study some of the molecular mechanisms associated with these heart diseases. "Ultimately they will help us to understand where some of the problems associated with these diseases arise and they could also provide models for the pharmaceutical industry to test new drugs. We will effectively be creating and studying these diseases in a dish.

"But it's important to say that we're at the very early stages of this research and it will take a considerable amount of time. There is still a great deal to learn about these techniques and much of our early work will involve understanding how we can make the hybrid cloning process as efficient as possible." The study is aimed at understanding the way power-producing structures in cells, called mitochondria, are passed from egg to embryo.